Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.54 |
| ▸ | CYBB | P04839 | 6/20 | 0.47 |
| ▸ | NOX1 | Q9Y5S8 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NOX5 | Q96PH1 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931769 | 0.82 | NOX4 (0.67) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL29523167 | 0.82 | NOX4 (0.67) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL29523426 | 0.80 | NOX4 (0.64) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL29522947 | 0.80 | NOX4 (0.56) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL14931779 | 0.71 | NOX4 (0.49) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL29523189 | 0.71 | NOX4 (0.49) | NOX4CYBBNOX1CYP3A4NOX5 | |
| SCHEMBL2214423 | 0.71 | NOX4 (0.79) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL2215660 | 0.70 | NOX4 (1.00) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL2217907 | 0.69 | NOX4 (0.72) | NOX4CYBBNOX1CYP3A4CYP2C8 | |
| SCHEMBL2219705 | 0.69 | NOX4 (0.91) | NOX4CYBBNOX1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776027-B1 | NADPH OXIDASE 4 INHIBITORS AND USE THEREOF | GENKYOTEX SUISSE SA (CH) | 2017-06-07 | — | — | EP | disclosed |