Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 20/20 | 0.59 |
| ▸ | CYBB | P04839 | 9/20 | 0.59 |
| ▸ | NOX1 | Q9Y5S8 | 8/20 | 0.59 |
| ▸ | NOX5 | Q96PH1 | 7/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14931738 | 0.93 | NOX4 (0.61) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL29522956 | 0.93 | NOX4 (0.61) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL14945120 | 0.91 | NOX4 (0.59) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL14931692 | 0.85 | NOX4 (0.60) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL29523135 | 0.85 | NOX4 (0.60) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL29523460 | 0.84 | NOX4 (0.66) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL14931607 | 0.84 | NOX4 (0.66) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL14931743 | 0.84 | NOX4 (0.75) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL29522756 | 0.84 | NOX4 (0.75) | NOX4CYBBNOX1NOX5CYP3A4 | |
| SCHEMBL14931623 | 0.84 | NOX4 (0.62) | NOX4CYBBNOX1NOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776027-B1 | NADPH OXIDASE 4 INHIBITORS AND USE THEREOF | GENKYOTEX SUISSE SA (CH) | 2017-06-07 | — | — | EP | disclosed |