Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14551158 | 0.91 | FAAH (0.52) | FAAHKCNH2TP53MAPTGRM5 | |
| SCHEMBL14482002 | 0.89 | FAAH (0.51) | FAAHKCNH2TP53MAPTRAB9A | |
| SCHEMBL14482388 | 0.89 | FAAH (0.70) | FAAHKCNH2TP53MAPTPOLB | |
| SCHEMBL2562946 | 0.82 | FAAH (0.62) | FAAHKCNH2TP53MAPTRXFP1 | |
| SCHEMBL2562294 | 0.82 | FAAH (0.60) | FAAHKCNH2TP53MAPTRXFP1 | |
| SCHEMBL18945015 | 0.78 | FAAH (0.65) | FAAHKCNH2TP53MAPTRXFP1 | |
| SCHEMBL14482074 | 0.75 | FAAH (0.56) | FAAHKCNH2 | |
| SCHEMBL1001917 | 0.74 | FAAH (0.69) | FAAHKCNH2MAPT | |
| SCHEMBL1001551 | 0.74 | FAAH (0.68) | FAAHKCNH2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1004012 | 0.74 | FAAH (0.63) | FAAHKCNH2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593102-B1 | OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |