Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11384633 | 0.82 | BLM (0.31) | BLM | |
| SCHEMBL1285149 | 0.79 | — | — | |
| SCHEMBL14338127 | 0.79 | BLM (0.52) | BLMLMNAPTPN1MEN1CYP3A4 | |
| SCHEMBL466796 | 0.79 | — | — | |
| SCHEMBL1286222 | 0.77 | CA1 (0.52) | LMNAMEN1CYP3A4KMT2A | |
| SCHEMBL466818 | 0.77 | — | — | |
| SCHEMBL11650641 | 0.77 | LMNA (0.42) | BLMLMNAPTPN1MEN1CYP3A4 | |
| SCHEMBL11382378 | 0.77 | SMN1; SMN2 (0.33) | LMNAMEN1KMT2A | |
| SCHEMBL22296737 | 0.75 | GSR (0.37) | — | |
| SCHEMBL6037327 | 0.75 | CA1 (0.50) | LMNAMEN1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661428-B1 | QUINOXALINES AND AZA-QUINOXALINES AS CRTH2 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |