SCHEMBL18945927

SCHEMBL18945927

C=C(C)c1ccc2nc(-c3ccc(F)cc3)c(CCCCC(=O)O)nc2c1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 19/20 0.47
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10212233 0.87 NAMPT (0.48) NAMPT
SCHEMBL9952967 0.87 NAMPT (0.53) NAMPTMAPT
SCHEMBL10210435 0.87 NAMPT (0.46) NAMPTMAPT
SCHEMBL15379575 0.87 NAMPT (0.52) NAMPTMAPT
SCHEMBL18945666 0.86 NAMPT (0.52) NAMPTMAPT
SCHEMBL10211158 0.85 NAMPT (0.47) NAMPTMAPT
SCHEMBL18945772 0.85 NAMPT (0.45) NAMPTMAPT
SCHEMBL15377371 0.84 NAMPT (0.51) NAMPTMAPT
SCHEMBL18945742 0.84 NAMPT (0.49) NAMPTMAPT
SCHEMBL9954437 0.84 NAMPT (0.46) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2661428-B1 QUINOXALINES AND AZA-QUINOXALINES AS CRTH2 RECEPTOR MODULATORS MERCK SHARP & DOHME (US) 2017-06-07 EP disclosed