Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextroamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.76 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.76 |
| ▸ | MAOA | P21397 | 1/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.76 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PNMT | P11086 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | LAP3 | P28838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levamfetamine SCHEMBL1978104 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL6465998 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Levamfetamine SCHEMBL396231 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL41204 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL4016537 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL8025793 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL2412146 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL7204032 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL41203 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL18949 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 143429 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122045978-A | Anomaly detection method and device based on deep multi-ellipsoid support vector data description | 中国科学院工程热物理研究所 | 2026-05-15 | — | — | CN | claimed |
| CN-121570739-A | Integrated assembled infrared therapeutic cabin | 中兆生物科技有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-12544385-B2 | Combination drug therapies for CNS disorders | JAVED MOHAMMAD (US) | 2026-02-10 | — | — | US | claimed |
| US-20260028676-A1 | METHODS FOR SELECTING MEDICATIONS FOR TREATING PATIENTS HAVING ATTENTION-DEFICIT HYPERACTIVITY DISORDER | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2026-01-29 | — | — | US | claimed |
| US-20260027043-A1 | EXTENDED RELEASE AMPHETAMINE TABLETS | TRIS PHARMA INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4683622-A1 | NON-DISTILLATIVE PROCESS FOR MANUFACTURING HIGH PURITY AMPHETAMINES | Pharmapotheca A, Inc. (US) | 2026-01-28 | — | — | EP | claimed |
| US-12534428-B2 | Non-distillative process for manufacturing high purity amphetamines | Pharmapotheca A, Inc. (US) | 2026-01-27 | — | — | US | claimed |
| US-12493860-B2 | Waste management system and method | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-12-09 | — | — | US | claimed |
| EP-4654966-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF OBESITY AND DISEASES ASSOCIATED WITH FAT CELL ENLARGEMENT | MELLICELL, INC. (US) | 2025-12-03 | — | — | EP | claimed |
| US-20250352466-A1 | EXTENDED RELEASE AMPHETAMINE TABLETS | TRIS PHARMA INC (US) | 2025-11-20 | — | — | US | claimed |
| US-3998244-A | Drip irrigation valve with helical flow path | BENTLEY CLARENCE | 1976-12-21 | — | — | US | claimed |
| US-3996749-A | Method and plants for producing, storing, modulating and distributing energy | COMPAGNIE FRANCAISE D'ETUDES ET DE CONSTRUCTION "TECHNIP" (FR) | 1976-12-14 | — | — | US | claimed |
| US-3995436-A | Apparatus for uniform dispersion of digested effluent | DIGGS RICHARD E | 1976-12-07 | — | — | US | claimed |
| US-3989132-A | Ribbon storage and transport mechanism | GENERAL ELECTRIC COMPANY (US) | 1976-11-02 | — | — | US | claimed |
| US-3966871-A | Method and apparatus for inspecting tubular cavities | KRAFTWERK UNION AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | claimed |
| US-3962069-A | SYSTEM FOR TREATING SLUDGE | INOUE-JAPAN RESEARCH INC. (JA) | 1976-06-08 | — | — | US | claimed |
| US-3955615-A | Twin-belt continuous casting apparatus | HAZELETT STRIP-CASTING CORPORATION (US) | 1976-05-11 | — | — | US | claimed |
| US-3953390-A | MINERAL PARTICLES, BINDERS | SOCIETE CHIMIQUE, ROUTIERE ET D'ENTREPRISE GENERALE (S.C.R.E.G.) (FR) | 1976-04-27 | — | — | US | claimed |
| US-3940924-A | Rotary engine | MIYADA THOMAS SANFRAN | 1976-03-02 | — | — | US | claimed |
| US-3937274-A | Belt back-up apparatus and coolant application means for twin-belt casting machines | HAZELETT STRIP-CASTING CORPORATION (US) | 1976-02-10 | — | — | US | claimed |