Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextroamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.76 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.76 |
| ▸ | MAOA | P21397 | 1/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.76 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | PNMT | P11086 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | LAP3 | P28838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levamfetamine SCHEMBL1978104 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL6465998 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Levamfetamine SCHEMBL396231 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL41204 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL4016537 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL8025793 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL2412146 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL18948 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL41203 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL18949 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107830007-A | A kind of quick switching hydraulic switch valve | 烟台华特液压机械有限公司 | 2018-03-23 | — | — | CN | claimed |
| CN-206839362-U | Tin cream adding set | 深圳市敏佳捷自动化科技有限公司 | 2018-01-05 | — | — | CN | claimed |
| CN-205403235-U | Multiple -effect absorption heat pump unit | 南京索罗英辰新能源有限公司 | 2016-07-27 | — | — | CN | claimed |
| CN-105546867-A | Multiple-effect absorption heat pump unit | NANJING SUOLUO YINGCHEN NEW ENERGY CO LTD | 2016-05-04 | — | — | CN | claimed |
| CN-205182365-U | Novel screen cloth | ZHEJIANG TIANTAI HUAYU IND CLOTH CO LTD | 2016-04-27 | — | — | CN | claimed |
| CN-105107435-A | Fluidized reactor and method for processing ore through reactor | SICHUAN MINGXIN INVEST CO LTD | 2015-12-02 | — | — | CN | claimed |
| CN-207047995-U | A kind of rainwater treatment device and sewerage system | 重庆交通大学 | 2018-02-27 | — | — | CN | disclosed |
| CN-206839362-U | Tin cream adding set | 深圳市敏佳捷自动化科技有限公司 | 2018-01-05 | — | — | CN | disclosed |
| CN-206617310-U | A kind of water cut-off pump pump head | 吴瑞昌 | 2017-11-07 | — | — | CN | disclosed |
| CN-206617310-U | A kind of water cut-off pump pump head | 吴瑞昌 | 2017-11-07 | — | — | CN | disclosed |
| CN-206499724-U | A kind of multi-functional intelligent transfusion monitor | 肖年盛 | 2017-09-19 | — | — | CN | disclosed |
| CN-105107435-B | A kind of fluidized reactor and the method using the reactor for treatment ore | 四川省明信投资有限公司 | 2017-06-30 | — | — | CN | disclosed |
| CN-104675610-B | High-temperature-resistant mud turbine generator | 北京精密机电控制设备研究所 | 2017-05-10 | — | — | CN | disclosed |
| CN-1704650-A | Gas radiation furnace | LG ELECTRONICS TIANJIN (CN) | 2005-12-07 | — | — | CN | disclosed |
| CN-2579499-Y | Dismounting type self flushing filter | YAN LIN (CN) | 2003-10-15 | — | — | CN | disclosed |
| EP-1349571-A2 | ROTAVIRUS ENTEROTOXIN NSP4 AND METHODS OF USING SAME | BAYLOR COLLEGE OF MEDICINE (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002036172-A2 | ROTAVIRUS ENTEROTOXIN NSP4 AND METHODS OF USING SAME | BAYLOR COLLEGE OF MEDICINE (US) | 2002-05-10 | — | — | WO | disclosed |
| EP-1166120-A1 | NOVEL SEMICONDUCTOR NANOPARTICLES FOR ANALYSIS OF BLOOD CELL POPULATIONS | Coulter International Corp. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058731-A1 | NOVEL SEMICONDUCTOR NANOPARTICLES FOR ANALYSIS OF BLOOD CELL POPULATIONS | COULTER INTERNATIONAL CORP. (US) | 2000-10-05 | — | — | WO | disclosed |
| CN-2369107-Y | Cut-off controllable valve for gas steam water heater | YANG BIN (CN) | 2000-03-15 | — | — | CN | disclosed |