SCHEMBL18949253

SCHEMBL18949253

C=C/C(C)=C\C[C@@H]1[C@@]2(C)CCCC(C)(C)C2CC[C@@]1(C)Br

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
MAPT P10636 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C9 P11712 2/20 0.46
TSHR P16473 2/20 0.46
CYP2C19 P33261 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
POLB P06746 1/20 0.45
TRPV1 Q8NER1 1/20 0.41
TRPA1 O75762 2/20 0.40
PNLIP P16233 3/20 0.38
PTPN2 P17706 2/20 0.38
PTPN1 P18031 2/20 0.38
CYP19A1 P11511 2/20 0.36
IDO1 P14902 1/20 0.32
UGT2B7 P16662 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15220009 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL18089046 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL9549996 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL8731628 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL541382 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL25669585 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL9550004 0.87 ALDH1A1 (0.57) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL19569919 0.82 ALDH1A1 (0.45) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL18076254 0.80 MAPT (0.43) ALDH1A1MAPTCYP3A4CYP2C9TSHR
SCHEMBL18089047 0.80 MAPT (0.43) ALDH1A1MAPTCYP3A4CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9677091-B2 Diterpene synthases and method for producing diterpenoids THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2017-06-13 US disclosed