SCHEMBL18949572

SCHEMBL18949572

C/N=C(\NCc1ccc(S(=O)(=O)c2cncc(F)c2)cc1)Nc1ccncc1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 20/20 0.63
CYP2C9 P11712 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18949579 0.88 NAMPT (0.63) NAMPT
SCHEMBL159550 0.87 NAMPT (0.68) NAMPTCYP2C9
SCHEMBL159551 0.87 NAMPT (0.68) NAMPTCYP2C9
SCHEMBL18949511 0.87 NAMPT (0.65) NAMPT
SCHEMBL18949655 0.86 NAMPT (0.66) NAMPT
SCHEMBL18949586 0.84 NAMPT (0.65) NAMPT
SCHEMBL18949594 0.83 NAMPT (0.62) NAMPT
SCHEMBL18949571 0.82 NAMPT (0.61) NAMPT
SCHEMBL18949584 0.81 NAMPT (0.62) NAMPT
SCHEMBL18949656 0.81 NAMPT (0.69) NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9676721-B2 Compounds and compositions for the inhibition of NAMPT FORMA TM, LLC (US) 2017-06-13 US disclosed