Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 20/20 | 0.56 |
| ▸ | GIPR | P48546 | 8/20 | 0.54 |
| ▸ | VIPR2 | P41587 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.54 |
| ▸ | VIPR1 | P32241 | 1/20 | 0.54 |
| ▸ | DUSP2 | Q05923 | 1/20 | 0.54 |
| ▸ | GLP1R | P43220 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895066 | 1.00 | GCGR (0.56) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL1896576 | 0.84 | PTPN1 (0.50) | CYP1A2CYP2C9 | |
| SCHEMBL1896573 | 0.84 | PTPN1 (0.50) | CYP1A2CYP2C9 | |
| SCHEMBL2520140 | 0.82 | GCGR (0.57) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL12668244 | 0.80 | NPC1 (0.56) | GCGRGIPR | |
| SCHEMBL1895496 | 0.80 | NPC1 (0.56) | GCGRGIPR | |
| SCHEMBL2669963 | 0.79 | GCGR (0.55) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL12836861 | 0.76 | GCGR (0.58) | GCGRGIPRVIPR2CYP1A2CYP3A4 | |
| SCHEMBL9951168 | 0.74 | NPC1 (0.71) | — | |
| SCHEMBL3197432 | 0.74 | NPC1 (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143673-A1 | Methods For Treating Heart Failure Using Glucagon Receptor Antagonists | REMD Biotherapeutics, Inc | 2017-05-25 | — | — | US | disclosed |
| US-7935713-B2 | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. (US) | 2011-05-03 | — | — | US | disclosed |
| US-20090105310-A1 | Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds and Methods of Use | MERCK SHARP & DOHME LLC | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105310-A1 | Glucagon Receptor Antagonist Compounds, Compositions Containing Such Compounds and Methods of Use | GCGR, GLP1R, GPR119 | GCGR 1/4885GIPR 4/4885VIPR2 30/4885 |
| US-20170143673-A1 | Methods For Treating Heart Failure Using Glucagon Receptor Antagonists | GLP1R, GCGR, GIPR | GCGR 2/4885GIPR 3/4885VIPR2 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.