Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.77 |
| ▸ | MAPT | P10636 | 11/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.77 |
| ▸ | POLB | P06746 | 9/20 | 0.77 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.77 |
| ▸ | PKM | P14618 | 6/20 | 0.77 |
| ▸ | BLM | P54132 | 6/20 | 0.77 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.77 |
| ▸ | HPGD | P15428 | 5/20 | 0.77 |
| ▸ | THRB | P10828 | 4/20 | 0.77 |
| ▸ | RECQL | P46063 | 4/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.77 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.71 |
| ▸ | BID | P55957 | 1/20 | 0.71 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856578 | 0.87 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL15814086 | 0.86 | MEN1 (0.84) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL13856422 | 0.84 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL26294993 | 0.80 | MEN1 (0.73) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL24277912 | 0.79 | MEN1 (0.74) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL26293058 | 0.79 | MEN1 (0.78) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL26294624 | 0.79 | MEN1 (0.86) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL13856429 | 0.78 | MEN1 (1.00) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL26293182 | 0.78 | MEN1 (0.82) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL26295615 | 0.77 | KMT2A (0.75) | MEN1KMT2AMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9504676-B2 | Molecules inhibiting a metabolic pathway involving the Syk protein tyrosine kinase and method for identifying said molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-11-29 | — | — | US | disclosed |
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-06-26 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | SYK, BTK, TYRO3 | MEN1 4288/4885KMT2A 1901/4885MAPT 4486/4885 |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | SYK, BTK, TYRO3 | MEN1 4288/4885KMT2A 1901/4885MAPT 4486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.