⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127986 | 0.89 | — | — | |
| SCHEMBL12128019 | 0.79 | — | — | |
| SCHEMBL16518854 | 0.72 | — | — | |
| SCHEMBL1404038 | 0.70 | SLC18A3 (0.44) | — | |
| Hydrochloric Acid SCHEMBL29131458 | 0.70 | CHRNA7 (0.35) | — | |
| SCHEMBL30667167 | 0.70 | OPRM1 (0.38) | — | |
| SCHEMBL3076098 | 0.68 | — | — | |
| SCHEMBL19468663 | 0.68 | — | — | |
| SCHEMBL18821982 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL31329690 | 0.67 | TDP1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519418-A1 | BRIDGED PIPERIDINE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2019-08-07 | — | — | EP | disclosed |
| EP-3475279-A1 | TRIAZOLOPYRIDINES AS GAMMA-SECRETASE MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2019-05-01 | — | — | EP | disclosed |
| EP-3386978-A1 | BRIDGED PIPERIDINE DERIVATIVES | H. Hoffnabb-La Roche Ag (CH) | 2018-10-17 | — | — | EP | disclosed |
| WO-2018060300-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-04-05 | — | — | WO | disclosed |
| WO-2018001918-A1 | TRIAZOLOPYRIDINES AS GAMMA-SECRETASE MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-04 | — | — | WO | disclosed |
| WO-2017097728-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-15 | — | — | WO | disclosed |