Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 11/20 | 0.53 |
| ▸ | NT5E | P21589 | 3/20 | 0.48 |
| ▸ | STK10 | O94804 | 6/20 | 0.46 |
| ▸ | SLK | Q9H2G2 | 6/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18953417 | 0.88 | SLK (0.44) | CXCR2STK10SLKCLK2GSK3A | |
| SCHEMBL18953476 | 0.82 | CXCR2 (0.56) | CXCR2NT5ECXCR1 | |
| SCHEMBL4648630 | 0.77 | CXCR2 (0.71) | CXCR2NT5ECXCR1 | |
| SCHEMBL18953660 | 0.77 | NT5E (0.58) | CXCR2NT5ECXCR1 | |
| SCHEMBL18953503 | 0.74 | CXCR2 (0.48) | CXCR2NT5ECXCR1 | |
| SCHEMBL18953327 | 0.73 | CXCR2 (0.67) | CXCR2NT5ECXCR1 | |
| SCHEMBL18953369 | 0.73 | CXCR2 (0.76) | CXCR2NT5ECXCR1 | |
| SCHEMBL18953475 | 0.72 | CXCR2 (0.44) | CXCR2NT5E | |
| SCHEMBL18953437 | 0.69 | CXCR2 (0.72) | CXCR2NT5ECXCR1 | |
| SCHEMBL18953528 | 0.67 | CXCR2 (0.44) | CXCR2NT5ESTK10SLKCXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017098421-A1 | BENZOTHIADIAZINE COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |