Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.71 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18953327 | 0.86 | CXCR2 (0.67) | CXCR2CXCR1CYP2C9NT5E | |
| SCHEMBL18953369 | 0.86 | CXCR2 (0.76) | CXCR2CXCR1CYP2C9NT5E | |
| SCHEMBL4649502 | 0.86 | CXCR2 (0.69) | CXCR2CXCR1CYP2C9NT5E | |
| SCHEMBL4698274 | 0.86 | CXCR2 (0.74) | CXCR2CXCR1CYP2C9 | |
| SCHEMBL4687691 | 0.83 | CXCR2 (1.00) | CXCR2CXCR1CYP2C9NT5E | |
| SCHEMBL18953660 | 0.78 | NT5E (0.58) | CXCR2CXCR1NT5E | |
| SCHEMBL18953418 | 0.77 | CXCR2 (0.53) | CXCR2CXCR1NT5E | |
| SCHEMBL18953476 | 0.77 | CXCR2 (0.56) | CXCR2CXCR1NT5E | |
| SCHEMBL18953368 | 0.76 | CXCR2 (0.62) | CXCR2CXCR1 | |
| SCHEMBL18953325 | 0.76 | CXCR2 (0.54) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631559-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | claimed |
| US-20060122173-A1 | Il-8 receptor antagonists | BUSCH-PETERSEN JAKOB | 2006-06-08 | — | — | US | claimed |
| EP-1631559-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005000231-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |
| US-20060122173-A1 | Il-8 receptor antagonists | BUSCH-PETERSEN JAKOB | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122173-A1 | Il-8 receptor antagonists | CXCL8, CCR8, IL1RN | CXCR2 9/4885CXCR1 13/4885CYP2C9 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.