Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SI | P14410 | 1/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15480444 | 0.83 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL18956343 | 0.83 | ALDH1A1 (0.70) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL15480447 | 0.82 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL15480448 | 0.82 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL15480450 | 0.82 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL15480445 | 0.82 | ALDH1A1 (0.67) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL29411401 | 0.80 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL21045302 | 0.80 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL17186221 | 0.78 | SMN1; SMN2 (0.61) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL11311373 | 0.78 | NPC1 (0.61) | ALDH1A1NPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386976-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | Research Triangle Institute, International (US) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017100558-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2017-06-15 | — | — | WO | disclosed |