Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895836 | 0.93 | ANO1 (0.56) | ALDH1A1LMNASMN1; SMN2HTTGALR3 | |
| SCHEMBL1952340 | 0.82 | MEN1 (0.64) | ALDH1A1LMNASMN1; SMN2HTTCYP2C9 | |
| SCHEMBL1954139 | 0.82 | SMN1; SMN2 (0.67) | ALDH1A1LMNASMN1; SMN2HTTGALR3 | |
| SCHEMBL1954228 | 0.78 | RAB9A (0.52) | ALDH1A1LMNASMN1; SMN2HTTCYP2C9 | |
| SCHEMBL1954102 | 0.77 | ANO1 (0.61) | ALDH1A1SMN1; SMN2HTTPKMANO1 | |
| SCHEMBL1894890 | 0.76 | ANO1 (0.43) | ALDH1A1LMNACYP2C9CYP2C19HPGD | |
| SCHEMBL1951572 | 0.74 | MEN1 (0.58) | ALDH1A1LMNASMN1; SMN2HTTCYP2C9 | |
| SCHEMBL1950364 | 0.73 | ANO1 (0.59) | ANO1 | |
| SCHEMBL1951578 | 0.73 | SMN1; SMN2 (0.54) | ALDH1A1LMNASMN1; SMN2HTTGALR3 | |
| SCHEMBL1954403 | 0.73 | ANO1 (0.60) | ANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |