Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGT | O15294 | 7/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544683 | 1.00 | OGT (0.67) | OGTUSP2GFERALDH1A1KDM4E | |
| SCHEMBL17406956 | 1.00 | OGT (0.67) | OGTUSP2GFERALDH1A1KDM4E | |
| SCHEMBL17406948 | 0.85 | OGT (0.51) | OGTUSP2ALDH1A1PKMKMT2A | |
| SCHEMBL2633965 | 0.85 | OGT (0.51) | OGTUSP2ALDH1A1PKMKMT2A | |
| SCHEMBL17406934 | 0.85 | ALDH1A1 (0.58) | OGTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL4544668 | 0.84 | OGT (0.66) | OGTUSP2ALDH1A1PKMKMT2A | |
| SCHEMBL17406957 | 0.84 | OGT (0.66) | OGTUSP2ALDH1A1PKMKMT2A | |
| SCHEMBL18965264 | 0.84 | OGT (0.66) | OGTUSP2ALDH1A1PKMKMT2A | |
| SCHEMBL17406949 | 0.83 | ALDH1A1 (0.62) | OGTALDH1A1PKMKMT2AMEN1 | |
| SCHEMBL18960081 | 0.82 | KDM4E (0.49) | OGTUSP2ALDH1A1KDM4EADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166558-A1 | O-GLCNAC TRANSFERASE (OGT) INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166558-A1 | O-GLCNAC TRANSFERASE (OGT) INHIBITORS AND USES THEREOF | OGA, OGT, CSGALNACT1 | OGT 2/4885USP2 2308/4885GFER 1096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.