Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | PPP5C | P53041 | 1/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18118481 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18107971 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18107970 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18108272 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18107969 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18107569 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18118480 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18107572 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18107973 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 | |
| SCHEMBL18108269 | 1.00 | GBA1 (0.49) | GBA1THRBLMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8496917-B2 | Compositions and methods for improving skin appearance | SYTHEON LTD (US) | 2013-07-30 | — | — | US | disclosed |
| US-20130183257-A1 | COMPOSITIONS AND METHODS FOR IMPROVING SKIN APPEARANCE | SYTHEON LTD. (US) | 2013-07-18 | — | — | US | disclosed |
| EP-2498772-A2 | COMPOSITION AND METHODS FOR IMPROVING SKIN APPEARANCE | Sytheon Ltd. (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059866-A2 | COMPOSITION AND METHODS FOR IMPROVING SKIN APPEARANCE | SYTHEON LTD. (US) | 2011-05-19 | — | — | WO | disclosed |
| US-20110117036-A1 | Compositions and Methods for Improving Skin Appearance | SYTHEON LIMITED (US) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110117036-A1 | Compositions and Methods for Improving Skin Appearance | CUTA, C5, C1S | GBA1 2100/4885THRB 4744/4885LMNA 1937/4885 |
| US-20130183257-A1 | COMPOSITIONS AND METHODS FOR IMPROVING SKIN APPEARANCE | CUTA, C5, C1S | GBA1 2100/4885THRB 4744/4885LMNA 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.