Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | MGLL | Q99685 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131223 | 0.83 | MAOB (0.53) | CA1HDAC2ALDH1A1HDAC1HDAC6 | |
| SCHEMBL76159 | 0.80 | CA1 (0.62) | TP53CA1MGLLHDAC2MMP3 | |
| SCHEMBL76158 | 0.80 | CA1 (0.62) | TP53CA1MGLLHDAC2MMP3 | |
| SCHEMBL9171323 | 0.80 | CA1 (0.62) | TP53CA1MGLLHDAC2MMP3 | |
| SCHEMBL657316 | 0.80 | TP53 (0.57) | TP53CA1MGLLHDAC2MMP3 | |
| SCHEMBL26604330 | 0.80 | TP53 (0.57) | TP53CA1MGLLHDAC2MMP3 | |
| SCHEMBL27518435 | 0.79 | CA1 (0.56) | TP53CA1MGLLHDAC2MMP3 | |
| SCHEMBL338880 | 0.78 | CYP19A1 (0.61) | TP53CA1MGLLALDH1A1MEN1 | |
| SCHEMBL11548251 | 0.78 | CA1 (0.60) | TP53CA1MGLLHDAC2ALDH1A1 | |
| SCHEMBL11548255 | 0.78 | CA1 (0.60) | TP53CA1MGLLHDAC2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377697-B2 | Process and intermediates | NOVARTIS AG (CH) | 2019-08-13 | — | — | US | disclosed |
| WO-2017098430-A1 | NEW PROCESS AND INTERMEDIATES | NOVARTIS AG (CH) | 2017-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377697-B2 | Process and intermediates | MME, ACE, DNPEP | TP53 3628/4885CA1 3396/4885MGLL 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.