Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18952685 | 1.00 | GPR119 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL23881623 | 1.00 | GPR119 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL18971233 | 1.00 | GPR119 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL23881624 | 1.00 | GPR119 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL30540111 | 0.89 | PSEN1 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL21050357 | 0.89 | PSEN1 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL21050356 | 0.89 | PSEN1 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL20609200 | 0.89 | PSEN1 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL18970962 | 0.89 | PSEN1 (0.41) | GPR119JAK3BTKRETMAP4K4 | |
| SCHEMBL21050358 | 0.89 | PSEN1 (0.41) | GPR119JAK3BTKRETMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386978-B1 | BRIDGED PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| WO-2017097728-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-15 | — | — | WO | disclosed |