Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 9/20 | 0.59 |
| ▸ | PLAU | P00749 | 3/20 | 0.59 |
| ▸ | ELANE | P08246 | 3/20 | 0.59 |
| ▸ | F2 | P00734 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.54 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29459644 | 0.91 | PTGER4 (0.61) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL24273650 | 0.91 | PTGER4 (0.61) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL1214430 | 0.90 | PTGER4 (0.62) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL2433523 | 0.90 | PTGER4 (0.68) | PTGER4PLAUELANEF2CNR1 | |
| SCHEMBL19381384 | 0.89 | PTGER4 (0.58) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL3428140 | 0.87 | PTGER4 (0.52) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL3430873 | 0.86 | PTGER4 (0.51) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL8426872 | 0.85 | CNR1 (0.57) | PTGER4ELANECYP1A2SMN1; SMN2SLC16A3 | |
| SCHEMBL1214836 | 0.85 | ELANE (0.64) | PTGER4PLAUELANEF2CYP1A2 | |
| SCHEMBL7745247 | 0.84 | ELANE (0.60) | PTGER4PLAUELANEF2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423379-B | Substituted 3-indazole Mcl-1 protein inhibitor, preparation method and application | 湖南科技大学 | 2021-08-03 | — | — | CN | disclosed |
| CN-111423379-A | Substituted 3-indazole Mcl-1 protein inhibitor, preparation method and application | 湖南科技大学 | 2020-07-17 | — | — | CN | disclosed |
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |
| US-7790761-B2 | Blockade of voltage dependent sodium channels | UNIVERSITY COLLEGE LONDON (GB) | 2010-09-07 | — | — | US | disclosed |
| US-20060100248-A1 | Blockade of voltage dependent sodium channels | GARTHWAITE GITI | 2006-05-11 | — | — | US | disclosed |
| US-7009056-B2 | Blockade of voltage dependent sodium channels | UNIVERSITY COLLEGE LONDON (GB) | 2006-03-07 | — | — | US | disclosed |
| US-20030171403-A1 | Blockade of voltage dependent sodium channels | UNIVERSITY COLLEGE LONDON (GB) | 2003-09-11 | — | — | US | disclosed |
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171403-A1 | Blockade of voltage dependent sodium channels | CACNA1F, SCNN1B, CACNA1B | PTGER4 1250/4885PLAU 4098/4885ELANE 2277/4885 |
| US-20060100248-A1 | Blockade of voltage dependent sodium channels | CACNA1I, CACNA1F, CACNA1C | PTGER4 1123/4885PLAU 3885/4885ELANE 2216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.