Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | FPR1 | P21462 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12668776 | 0.96 | MEN1 (0.75) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL1898032 | 0.92 | MEN1 (0.68) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL30774054 | 0.92 | MEN1 (0.68) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL1900564 | 0.88 | KMT2A (0.74) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL30774080 | 0.88 | KMT2A (0.74) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL12668739 | 0.86 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL1897477 | 0.85 | ALDH1A1 (0.71) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL30774052 | 0.83 | RXFP1 (0.82) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL1898478 | 0.83 | RXFP1 (0.82) | MEN1KMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL12668757 | 0.82 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1KDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9504676-B2 | Molecules inhibiting a metabolic pathway involving the Syk protein tyrosine kinase and method for identifying said molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-11-29 | — | — | US | disclosed |
| US-9504676-B2 | Molecules inhibiting a metabolic pathway involving the Syk protein tyrosine kinase and method for identifying said molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-11-29 | — | — | US | disclosed |
| US-9504676-B2 | Molecules inhibiting a metabolic pathway involving the Syk protein tyrosine kinase and method for identifying said molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-11-29 | — | — | US | disclosed |
| EP-2285366-B1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NAT RECH SCIENT (FR) | 2015-02-25 | — | — | EP | disclosed |
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-06-26 | — | — | US | disclosed |
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-06-26 | — | — | US | disclosed |
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-06-26 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179679-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | SYK, BTK, TYRO3 | MEN1 4288/4885KMT2A 1901/4885ALDH1A1 3595/4885 |
| US-20110112098-A1 | MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES | SYK, BTK, TYRO3 | MEN1 4288/4885KMT2A 1901/4885ALDH1A1 3595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.