Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494826 | 0.84 | HPGD (0.59) | PKMHPGDKMT2APHGDHHSP90AA1 | |
| SCHEMBL18961647 | 0.81 | ERN1 (0.53) | PKMHPGDKMT2APHGDHKDM4E | |
| SCHEMBL1901121 | 0.81 | ERN1 (0.76) | PKMHPGDKMT2AERN1 | |
| SCHEMBL2786906 | 0.74 | HPGD (0.73) | PKMHPGDKMT2APHGDHKDM4E | |
| SCHEMBL487574 | 0.73 | PKM (0.77) | PKMHPGDKMT2APHGDHKDM4E | |
| SCHEMBL16079573 | 0.73 | KDM4E (0.75) | PKMHPGDKMT2APHGDHKDM4E | |
| SCHEMBL12675424 | 0.73 | ERN1 (0.76) | PKMHPGDERN1 | |
| SCHEMBL2199279 | 0.72 | PHGDH (0.71) | PKMHPGDKMT2APHGDHKDM4E | |
| SCHEMBL16592967 | 0.72 | ERN1 (0.60) | PKMHPGDPHGDHERN1AKR1C3 | |
| SCHEMBL2378698 | 0.72 | PKM (0.75) | PKMHPGDKMT2APHGDHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496230-A1 | IRE-1 ALPHA INHIBITORS | MannKind Corporation (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011056744-A1 | IRE-1 α INHIBITORS | MANNKIND CORPORATION (US) | 2011-05-12 | — | — | WO | disclosed |