Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.55 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.55 |
| ▸ | TNF | P01375 | 5/20 | 0.55 |
| ▸ | IL1B | P01584 | 3/20 | 0.55 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15912588 | 0.81 | CRBN (0.56) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL8597854 | 0.80 | EGFR (0.47) | ALDH1A1 | |
| SCHEMBL8599835 | 0.77 | MAOA (0.54) | HTTALDH1A1 | |
| SCHEMBL2253151 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2253145 | 0.77 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL12373360 | 0.76 | CRBN (0.78) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL16768188 | 0.76 | CRBN (0.49) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL2252809 | 0.76 | CRBN (0.78) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL18975879 | 0.76 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL16768259 | 0.75 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536706-B1 | ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2017-06-14 | — | — | EP | disclosed |