Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.83 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.83 |
| ▸ | STK25 | O00506 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | STK17B | O94768 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | FES | P07332 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | HCK | P08631 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6385833 | 0.91 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL8150230 | 0.91 | EGFR (1.00) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL6383772 | 0.89 | EGFR (0.88) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL6382071 | 0.87 | EGFR (0.84) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL8150053 | 0.87 | EGFR (0.84) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL1417860 | 0.86 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL1417858 | 0.86 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL6505775 | 0.86 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL6505779 | 0.86 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL6384606 | 0.86 | EGFR (1.00) | EGFRERBB2SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42376-E1 | Substituted 3-cyanoquinolines | WYETH HOLDINGS CORPORATION (US) | 2011-05-17 | — | — | US | claimed |
| US-6297258-B1 | USEFUL AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE. | AMERICAN CYANAMID COMPANY | 2001-10-02 | — | — | US | claimed |