Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 19/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505779 | 1.00 | EGFR (0.79) | EGFRERBB2 | |
| SCHEMBL1417860 | 0.89 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL1417858 | 0.89 | EGFR (0.82) | EGFRERBB2 | |
| SCHEMBL6384606 | 0.88 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL6380477 | 0.87 | EGFR (0.86) | EGFRERBB2 | |
| SCHEMBL1897656 | 0.86 | EGFR (0.83) | EGFRERBB2 | |
| SCHEMBL1418468 | 0.85 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL1418471 | 0.85 | EGFR (0.60) | EGFRERBB2 | |
| SCHEMBL8150230 | 0.85 | EGFR (1.00) | EGFRERBB2 | |
| SCHEMBL6385833 | 0.85 | EGFR (1.00) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |