Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | GRN | P28799 | 2/20 | 0.66 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | HTR1E | P28566 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898164 | 0.86 | NPSR1 (0.89) | NPSR1GRNSORT1MAPTGAA | |
| SCHEMBL148799 | 0.86 | NPSR1 (0.67) | NPSR1NPC1RAB9AKMT2AGRN | |
| SCHEMBL1897821 | 0.84 | NPSR1 (0.78) | NPSR1RAB9AKMT2AGRNSORT1 | |
| SCHEMBL1899685 | 0.84 | NPSR1 (0.85) | NPSR1GRNSORT1MAPTGAA | |
| SCHEMBL1899459 | 0.83 | NPSR1 (1.00) | NPSR1NPC1RAB9AKMT2AGRN | |
| SCHEMBL175204 | 0.82 | NPSR1 (0.62) | NPSR1NPC1RAB9AKMT2AGRN | |
| SCHEMBL1897555 | 0.82 | NPSR1 (0.74) | NPSR1NPC1RAB9AKMT2AGRN | |
| SCHEMBL143529 | 0.82 | NPSR1 (0.67) | NPSR1NPC1RAB9AKMT2AGRN | |
| SCHEMBL143851 | 0.82 | NPSR1 (0.81) | NPSR1GRNSORT1MAPTGAA | |
| SCHEMBL1900718 | 0.82 | NPSR1 (0.85) | NPSR1GRNSORT1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |