SCHEMBL18979059

SCHEMBL18979059

COC(=O)CC1(CSc2ccncc2-c2ccc(C#N)cc2)CC1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SLC22A12 Q96S37 13/20 0.56
▸ KDM4E B2RXH2 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ EGLN1 Q9GZT9 3/20 0.37
▸ CYP11B1 P15538 1/20 0.37
▸ CYP11B2 P19099 1/20 0.37
▸ KCNA5 P22460 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19240224 0.91 SLC22A12 (0.59) SLC22A12CYP11B1CYP11B2
SCHEMBL22938888 0.89 SLC22A12 (0.53) SLC22A12CYP11B1CYP11B2
SCHEMBL17540682 0.88 SLC22A12 (0.45) SLC22A12KDM4EL3MBTL1KCNA5
Darbinurad SCHEMBL17540573 0.88 SLC22A12 (0.72) SLC22A12
Darbinurad SCHEMBL31687456 0.88 SLC22A12 (0.72) SLC22A12
Darbinurad SCHEMBL21408205 0.87 SLC22A12 (0.70) SLC22A12
SCHEMBL18978870 0.87 SLC22A12 (0.59) SLC22A12
Darbinurad SCHEMBL21408193 0.86 SLC22A12 (0.58) SLC22A12
Darbinurad SCHEMBL29677364 0.86 SLC22A12 (0.58) SLC22A12
Darbinurad SCHEMBL21408206 0.86 SLC22A12 (0.58) SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3774733-B1 NOVEL SALT FORMS OF URAT-1 INHIBITORS INVENTISBIO CO LTD (CN) 2025-09-24 — — EP disclosed
US-11685720-B2 Salt forms of URAT-1 inhibitors InventisBio Co., Ltd. (CN) 2023-06-27 — — US disclosed
US-11685720-B2 Salt forms of URAT-1 inhibitors InventisBio Co., Ltd. (CN) 2023-06-27 — — US disclosed
US-11685720-B2 Salt forms of URAT-1 inhibitors InventisBio Co., Ltd. (CN) 2023-06-27 — — US disclosed
EP-3181557-B1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF INVENTISBIO CO LTD (CN) 2023-03-01 — — EP disclosed
US-20220371996-A1 NOVEL SALT FORMS OF URAT-1 INHIBITORS InventisBio Co., Ltd. (CN) 2022-11-24 — — US disclosed
US-11339127-B2 Salt forms of URAT-1 inhibitors InventisBio Co., Ltd. (CN) 2022-05-24 — — US disclosed
US-11339127-B2 Salt forms of URAT-1 inhibitors InventisBio Co., Ltd. (CN) 2022-05-24 — — US disclosed
CN-106573908-B Carboxylic acid compound, and preparation method and use thereof 益方生物科技(上海)股份有限公司 2021-02-05 — — CN disclosed
US-20210032204-A1 NOVEL SALT FORMS OF URAT-1 INHIBITORS InventisBio Co., Ltd. (CN) 2021-02-04 — — US disclosed
US-20180022736-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF InventisBio Co., Ltd. (CN) 2018-01-25 — — US disclosed
US-9856239-B1 Carboxylic acid compound, method for preparation thereof, and use thereof INVENTISBIO SHANGHAI LTD. (CN) 2018-01-02 — — US disclosed
US-9856239-B1 Carboxylic acid compound, method for preparation thereof, and use thereof INVENTISBIO SHANGHAI LTD. (CN) 2018-01-02 — — US disclosed
US-9809580-B2 Carboxylic acid compound, method for preparation thereof, and use thereof INVENTISBIO SHANGHAI LTD. (CN) 2017-11-07 — — US disclosed
US-9809580-B2 Carboxylic acid compound, method for preparation thereof, and use thereof INVENTISBIO SHANGHAI LTD. (CN) 2017-11-07 — — US disclosed
US-9809580-B2 Carboxylic acid compound, method for preparation thereof, and use thereof INVENTISBIO SHANGHAI LTD. (CN) 2017-11-07 — — US disclosed
US-20170233376-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF InventisBio Co., Ltd. (CN) 2017-08-17 — — US disclosed
US-20170233376-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF InventisBio Co., Ltd. (CN) 2017-08-17 — — US disclosed
US-20170233376-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF InventisBio Co., Ltd. (CN) 2017-08-17 — — US disclosed
EP-3181557-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF Shanghai Shaletech Technology Co., Ltd. (CN) 2017-06-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220371996-A1 NOVEL SALT FORMS OF URAT-1 INHIBITORS SLC5A1, SLC34A1, SLC10A1 SLC22A12 304/4885KDM4E 2929/4885L3MBTL1 1325/4885
US-20170233376-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF CA7, CYP2C9, CA9 SLC22A12 251/4885KDM4E 2447/4885L3MBTL1 4840/4885
US-11339127-B2 Salt forms of URAT-1 inhibitors SLC5A1, SLC34A1, SLC10A1 SLC22A12 365/4885KDM4E 3054/4885L3MBTL1 1280/4885
US-20210032204-A1 NOVEL SALT FORMS OF URAT-1 INHIBITORS SLC5A1, SLC34A1, SLC10A1 SLC22A12 304/4885KDM4E 2929/4885L3MBTL1 1325/4885
US-20180022736-A1 CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARATION THEREOF, AND USE THEREOF CA7, CYP2C9, CA9 SLC22A12 251/4885KDM4E 2447/4885L3MBTL1 4840/4885
US-11685720-B2 Salt forms of URAT-1 inhibitors SLC5A1, SLC34A1, SLC10A1 SLC22A12 365/4885KDM4E 3054/4885L3MBTL1 1280/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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