Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.68 |
| ▸ | INSR | P06213 | 3/20 | 0.68 |
| ▸ | IGF1R | P08069 | 3/20 | 0.68 |
| ▸ | EGFR | P00533 | 3/20 | 0.68 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.68 |
| ▸ | CDC7 | O00311 | 1/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.68 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.68 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | PAK4 | O96013 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532360 | 0.93 | EGFR (0.65) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL12628010 | 0.92 | ALK (0.64) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL1532325 | 0.91 | ALK (0.76) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL1817737 | 0.89 | ALK (0.64) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL1532357 | 0.86 | EGFR (0.68) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL12628011 | 0.85 | ALK (0.71) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL18408771 | 0.82 | ALK (0.72) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL31276403 | 0.82 | ALK (0.84) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL375524 | 0.81 | PTK2 (1.00) | ALKPTK2MAPK9MAPK10MAPK8 | |
| SCHEMBL29730430 | 0.81 | PTK2 (1.00) | ALKPTK2MAPK9MAPK10MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662195-B2 | Protein kinase conjugates and inhibitors | CELGENE CAR LLC (BM) | 2020-05-26 | — | — | US | disclosed |
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | CELGENE CAR LLC (BM) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174691-A1 | Protein Kinase Conjugates and Inhibitors | MAP3K20, ADK, TTK | ALK 789/4885PTK2 66/4885MAPK9 83/4885 |
| US-10662195-B2 | Protein kinase conjugates and inhibitors | MAP3K20, ADK, TTK | ALK 789/4885PTK2 66/4885MAPK9 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.