Sugi Predict

Sugi Predict / Compounds / SCHEMBL18980703

SCHEMBL18980703

SCHEMBL18980703

COc1ccc([C@H](NS(=O)(=O)c2ccc(C)cc2)c2ccc(Cl)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 1/20 0.54
▸ UTS2R Q9UKP6 1/20 0.52
▸ ALDH1A1 P00352 3/20 0.50
▸ FFAR4 Q5NUL3 2/20 0.50
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ EGFR P00533 2/20 0.48
▸ ERBB2 P04626 1/20 0.48
▸ CA12 O43570 1/20 0.48
▸ MMP2 P08253 1/20 0.48
▸ CA9 Q16790 1/20 0.48
▸ CA14 Q9ULX7 1/20 0.48
▸ TP53 P04637 1/20 0.47
▸ PPIA P62937 1/20 0.47
▸ LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18980705 1.00 CNR1 (0.54) CNR1UTS2RALDH1A1FFAR4MEN1
SCHEMBL19010047 0.88 CNR1 (0.55) CNR1ALDH1A1FFAR4MEN1KMT2A
SCHEMBL15871647 0.88 CNR1 (0.55) CNR1ALDH1A1FFAR4MEN1KMT2A
SCHEMBL18980854 0.86 CNR1 (0.54) CNR1ALDH1A1FFAR4MEN1KMT2A
SCHEMBL18980948 0.85 MAPT (0.56) UTS2RALDH1A1MEN1KMT2AEGFR
SCHEMBL29740753 0.85 MAPT (0.56) UTS2RALDH1A1MEN1KMT2AEGFR
SCHEMBL18980950 0.83 UTS2R (0.54) UTS2RALDH1A1MEN1KMT2AEGFR
SCHEMBL18980952 0.83 UTS2R (0.54) UTS2RALDH1A1MEN1KMT2AEGFR
SCHEMBL29259795 0.82 CNR1 (0.60) CNR1ALDH1A1FFAR4MEN1KMT2A
SCHEMBL28354122 0.80 CNR1 (0.77) CNR1ALDH1A1FFAR4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10118169-B2 Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis THE UNIVERSITY OF CHICAGO (US) 2018-11-06 — — US disclosed
US-20170173572-A1 CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-06-22 — — US disclosed
US-20170173572-A1 CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-06-22 — — US disclosed
US-20170173572-A1 CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-06-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170173572-A1 CHIRAL LIGAND-BASED METAL-ORGANIC FRAMEWORKS FOR BROAD-SCOPE ASYMMETRIC CATALYSIS POF1B, FGFR1, COASY CNR1 2276/4885UTS2R 3671/4885ALDH1A1 861/4885
US-10118169-B2 Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis POF1B, FGFR1, COASY CNR1 2276/4885UTS2R 3671/4885ALDH1A1 861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.