Sugi Predict

Sugi Predict / Compounds / SCHEMBL1898412

SCHEMBL1898412

SCHEMBL1898412

COCCNc1cc(N2CCN(C)CC2)ccc1C(=O)Nc1nn(C(=O)OC)c2c1CN(S(=O)(=O)c1cc(F)cc(F)c1)CC2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 10/20 0.56
▸ ALK Q9UM73 15/20 0.54
▸ INSR P06213 14/20 0.54
▸ AURKA O14965 3/20 0.54
▸ AURKB Q96GD4 3/20 0.54
▸ PLK4 O00444 2/20 0.40
▸ DAPK3 O43293 2/20 0.40
▸ NTRK1 P04629 2/20 0.40
▸ PRKCG P05129 2/20 0.40
▸ ROS1 P08922 2/20 0.40
▸ FER P16591 2/20 0.40
▸ LTK P29376 2/20 0.40
▸ FRK P42685 2/20 0.40
▸ MST1R Q04912 2/20 0.40
▸ PTK2 Q05397 2/20 0.40
▸ TNK2 Q07912 2/20 0.40
▸ NTRK3 Q16288 2/20 0.40
▸ MAP4K5 Q9Y4K4 2/20 0.40
▸ WEE1 P30291 1/20 0.40
▸ MAPK8 P45983 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1896206 0.96 IGF1R (0.54) IGF1RALKINSRAURKAAURKB
SCHEMBL1433657 0.96 IGF1R (0.54) IGF1RALKINSRAURKAAURKB
SCHEMBL4316899 0.95 IGF1R (0.57) IGF1RALKINSRAURKAAURKB
SCHEMBL1434141 0.94 IGF1R (0.52) IGF1RALKINSRAURKAAURKB
SCHEMBL1898586 0.93 IGF1R (0.51) IGF1RALKINSRAURKAAURKB
SCHEMBL1433784 0.90 ALK (0.55) IGF1RALKINSRAURKAAURKB
SCHEMBL1434126 0.90 ALK (0.55) IGF1RALKINSRAURKAAURKB
SCHEMBL1433782 0.90 ALK (0.55) IGF1RALKINSRAURKAAURKB
SCHEMBL1889356 0.87 IGF1R (0.73) IGF1RALKINSRAURKAAURKB
SCHEMBL1433807 0.86 ALK (0.53) IGF1RALKINSRAURKAAURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809337-B2 Carbamoyl derivatives of bicyclic carbonylamino-pyrazoles as prodrugs NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2014-08-19 — — US claimed
US-20130203770-A1 CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2013-08-08 — — US claimed
US-20110118278-A1 CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-19 — — US claimed
US-8809337-B2 Carbamoyl derivatives of bicyclic carbonylamino-pyrazoles as prodrugs NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2014-08-19 — — US disclosed
US-20130203770-A1 CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2013-08-08 — — US disclosed
US-20110118278-A1 CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130203770-A1 CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS DMPK, DCK, MAP3K19 IGF1R 1797/4885ALK 158/4885INSR 1921/4885
US-20110118278-A1 CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS DMPK, DCK, MAP3K19 IGF1R 1797/4885ALK 158/4885INSR 1921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.