Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | GMNN | O75496 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245414 | 0.90 | F2RL3 (0.67) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL5368291 | 0.89 | PDE5A (0.62) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL3077928 | 0.88 | PDE5A (0.70) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL3205820 | 0.88 | PDE5A (0.58) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL2961075 | 0.88 | PDE5A (0.70) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL14264654 | 0.88 | PDE5A (0.63) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1900992 | 0.88 | PDE5A (0.70) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL5365656 | 0.87 | PDE5A (0.65) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL2950681 | 0.87 | PDE5A (0.70) | PDE5AKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL4840627 | 0.87 | PDE5A (0.73) | PDE5AKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |
| US-7790761-B2 | Blockade of voltage dependent sodium channels | UNIVERSITY COLLEGE LONDON (GB) | 2010-09-07 | — | — | US | disclosed |
| US-7754751-B2 | Preferential inhibition of release of pro-inflammatory cytokines | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2010-07-13 | — | — | US | disclosed |
| EP-1512401-B1 | Enhancement of bone growth and inhibition of bone resorption | YUNG SHIN PHARMACEUTICAL IND (TW) | 2010-03-17 | — | — | EP | disclosed |
| EP-1512400-B1 | Treatment of neurodegenerative diseases | CARLSBAD TECHNOLOGY INC (US) | 2010-03-10 | — | — | EP | disclosed |
| EP-1425011-B1 | ENHANCEMENT OF LEARNING AND MEMORY AND TREATMENT OF AMNESIA | CARLSBAD TECHNOLOGY INC (US) | 2009-11-04 | — | — | EP | disclosed |
| US-7378532-B2 | Fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2008-05-27 | — | — | US | disclosed |
| US-7378532-B2 | Fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2008-05-27 | — | — | US | disclosed |
| US-7378532-B2 | Fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2008-05-27 | — | — | US | disclosed |
| EP-1425011-A4 | ENHANCEMENT OF LEARNING AND MEMORY AND TREATMENT OF AMNESIA | CARLSBAD TECHNOLOGY INC (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20030171403-A1 | Blockade of voltage dependent sodium channels | UNIVERSITY COLLEGE LONDON (GB) | 2003-09-11 | — | — | US | disclosed |
| US-20030105149-A1 | Enhancement of learning and memory and treatment of amnesia | CARLSBAD TECHNOLOGY, INC. | 2003-06-05 | — | — | US | disclosed |
| WO-2003024397-A2 | ENHANCEMENT OF LEARNING AND MEMORY AND TREATMENT OF AMNESIA | CARLSBAD TECHNOLOGY, INC. (US) | 2003-03-27 | — | — | WO | disclosed |
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| US-6387942-B2 | PYRAZOLYL COMPOUND; ANTICOAGULANTS, ANTIPROLIFERATIVE AGENT | YUNG SHIN PHARMACEUTICAL IND. CO. LTD (TW) | 2002-05-14 | — | — | US | disclosed |
| US-20020004518-A1 | Method of treating disorders related to protease-activated receptors-induced cell activation | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2002-01-10 | — | — | US | disclosed |
| EP-1166785-A1 | Use of pyrazole derivatives for inhibiting thrombin-induced platelet aggregation | Yung Shin Pharmeutical Ind. Co., Ltd. (TW) | 2002-01-02 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |
| EP-0667345-B1 | 1-Benzyl-3-(substituted aryl)-condensed pyrazole derivatives as inhibitors of platelet aggregation | YUNG SHIN PHARM IND CO LTD (TW) | 1999-09-29 | — | — | EP | disclosed |
| EP-0667345-A1 | 1-Benzyl-3-(substituted aryl)-condensed pyrazole derivatives as inhibitors of platelet aggregation | Yung Shin Pharm. Ind. Co. Ltd. (TW) | 1995-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171403-A1 | Blockade of voltage dependent sodium channels | CACNA1F, SCNN1B, CACNA1B | PDE5A 255/4885KDM4E 2368/4885ALDH1A1 1123/4885 |
| US-20030105149-A1 | Enhancement of learning and memory and treatment of amnesia | NR1H3, NR1H2, RORA | PDE5A 4531/4885KDM4E 3980/4885ALDH1A1 1070/4885 |
| US-20020004518-A1 | Method of treating disorders related to protease-activated receptors-induced cell activation | F2R, HPN, F2RL1 | PDE5A 3372/4885KDM4E 4548/4885ALDH1A1 2860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.