RORA

Nuclear receptor ROR-alpha · P35398 · RORA on Sugi Atlas →

22,551 patent compounds predicted against RORA, 15,391 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL29782 SCHEMBL29782 0.55 10/20
SCHEMBL29034 SCHEMBL29034 0.52 7/20
SCHEMBL1035417 SCHEMBL1035417 0.46 7/20
SCHEMBL97196 SCHEMBL97196 0.50 6/20
SCHEMBL435200 SCHEMBL435200 0.48 6/20
SCHEMBL80507 SCHEMBL80507 0.51 5/20
SCHEMBL279246 SCHEMBL279246 0.50 5/20
SCHEMBL398421 SCHEMBL398421 0.50 5/20
T091317 T091317 (SCHEMBL457231) 1.00 4/20
Fantridone Fantridone (SCHEMBL124109) 0.68 4/20
SCHEMBL97588 SCHEMBL97588 0.49 4/20
SCHEMBL559250 SCHEMBL559250 0.44 4/20
7-Oxocholesterol 7-Oxocholesterol (SCHEMBL231535) 1.00 3/20
7-Oxocholesterol 7-Oxocholesterol (SCHEMBL231536) 1.00 3/20
SCHEMBL281941 SCHEMBL281941 1.00 3/20
SCHEMBL281942 SCHEMBL281942 1.00 3/20
SCHEMBL281943 SCHEMBL281943 1.00 3/20
SCHEMBL289219 SCHEMBL289219 1.00 3/20
SCHEMBL532559 SCHEMBL532559 1.00 3/20
SCHEMBL532560 SCHEMBL532560 1.00 3/20

Clinical trials — most relevant to RORA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate PHASE4NOT_YET_RECRUITING
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
Role of Antioxidants Supplementation in Chronic Pancreatitis PHASE3COMPLETED
Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer. PHASE3UNKNOWN
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment PHASE2UNKNOWN
Fibrates in Pediatric Cholestasis PHASE2COMPLETED
Preoperative Bexarotene Treatment for Cushing's Disease PHASE1/PHASE2UNKNOWN
Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus PHASE2UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Oral NRX 194204 Study in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) PHASE2UNKNOWN
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis PHASE2ACTIVE_NOT_RECRUITING
A Study Evaluating Megestrol Acetate Modulation in Hormone Receptor Positive Advanced Breast Cancer PHASE2UNKNOWN
Meclizine for Hepatocellular Carcinoma PHASE1COMPLETED
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED
Effect of Liraglutide on Clock Genes nanUNKNOWN
Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients nanUNKNOWN
Investigation of Tumor Microenvironment After CRPC Along With Before and After Neoadjuvant Therapy for Prostate Cancer nanUNKNOWN
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes nanCOMPLETED
Gene Expression in Chronic Venous Leg Ulcers nanUNKNOWN
Phenotypic and Functional Profile of Peripheral Blood Lymphomonocytes in Seborrheic Dermatitis. nanCOMPLETED
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT nanCOMPLETED
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation nanCOMPLETED
The Role of Programmed Death Ligand -1 (Pdl-1) in Lung Cancer nanCOMPLETED
Retinoic Acid Homeostasis in Neuropsychiatric Diseases nanUNKNOWN
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Circadian Clock Gene Expression in Periodontal Disease nanCOMPLETED
Involvement of Pollutants in Atopic Dermatitis and Psoriasis nanUNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Role of FGF21 in Breast Cancer nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a RORA binder may also engage these)

ProteinNameSimilarity
P51448 1.000 P51448 →
F1QLY4 1.000 F1QLY4 →
Q0ZAQ8 1.000 Q0ZAQ8 →
P49882 1.000 P49882 →
Q64249 1.000 Q64249 →
P45446 1.000 P45446 →
P28700 1.000 P28700 →
P31396 1.000 P31396 →
O35507 1.000 O35507 →
Q8HYL6 1.000 Q8HYL6 →
P06212 1.000 P06212 →
P51129 1.000 P51129 →
P45448 1.000 P45448 →
Q28037 0.999 Q28037 →
P06211 0.999 P06211 →
Q9XSB5 0.999 Q9XSB5 →
A0JNE3 0.999 A0JNE3 →
Q95N78 0.999 Q95N78 →
Q6GN21 0.999 Q6GN21 →
P33242 0.999 P33242 →
P49883 0.999 P49883 →
A3RGC1 0.999 A3RGC1 →
P37234 0.999 P37234 →
Q9TU15 0.999 Q9TU15 →
Q06725 0.999 Q06725 →
RORB Nuclear receptor ROR-beta 0.998 landscape →
Q9QWM1 0.998 Q9QWM1 →
P49117 0.998 P49117 →
Q8R1B8 0.998 Q8R1B8 →
P50569 0.998 P50569 →