SCHEMBL18985115

SCHEMBL18985115

c1cc(C2=NCCC2)cc(C2=NCCC2)c1

nearest known ligand 0.67

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 12/20 0.67
CHRNA3 P32297 12/20 0.67
CHRNA7 P36544 2/20 0.61
ALDH1A1 P00352 1/20 0.60
CYP1A2 P05177 1/20 0.60
THRB P10828 1/20 0.60
CYP2C19 P33261 1/20 0.60
TSHR P16473 2/20 0.37
NISCH Q9Y2I1 2/20 0.36
KMT2A Q03164 1/20 0.36
GAA P10253 1/20 0.35
NOS3 P29474 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17398232 0.86 CHRNB4 (0.90) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL6558703 0.86 CHRNB4 (0.90) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL2807123 0.86 CHRNB4 (0.90) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL433117 0.86 CHRNB4 (0.90) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL165812 0.84 CHRNB4 (0.87) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL23054928 0.83 CHRNB4 (0.50) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL27495537 0.82 CHRNB4 (0.65) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL13114824 0.82 CHRNB4 (0.57) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL9583820 0.82 CHRNB4 (0.57) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2
SCHEMBL2806024 0.82 CHRNB4 (0.57) CHRNB4CHRNA3CHRNA7ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017099708-A1 CURING AGENTS FOR FLUORINATED ELASTOMERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-06-15 WO disclosed