Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 10/20 | 0.87 |
| ▸ | CHRNA3 | P32297 | 10/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895500 | 0.93 | CHRNB4 (1.00) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL6797483 | 0.91 | CHRNB4 (0.96) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL18985115 | 0.84 | CHRNB4 (0.67) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL895819 | 0.82 | CHRNB4 (0.67) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL20411025 | 0.81 | CHRNB4 (0.60) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL27584798 | 0.79 | ALDH1A1 (0.60) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL1357487 | 0.78 | CHRNB4 (0.56) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL24414772 | 0.77 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL15665457 | 0.77 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB | |
| SCHEMBL3574404 | 0.77 | CHRNB4 (0.55) | CHRNB4CHRNA3ALDH1A1CYP1A2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686616-A | Process for preparing an optically active amine | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1997-11-11 | — | — | US | claimed |
| US-20250391519-A1 | CHEMICAL SYNTHESIS PLATFORM | UNIV GLASGOW COURT (GB) | 2025-12-25 | — | — | US | disclosed |
| US-12459921-B2 | Isoindoline compound, preparation method, pharmaceutical composition and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2025-11-04 | — | — | US | disclosed |
| EP-4548355-A1 | CHEMICAL SYNTHESIS PLATFORM | The University Court Of The University Of Glasgow (GB) | 2025-05-07 | — | — | EP | disclosed |
| EP-4545515-A1 | BCL-2 INHIBITORS | BeiGene Switzerland GmbH (CH) | 2025-04-30 | — | — | EP | disclosed |
| US-20240376104-A1 | Bcl-2 Inhibitors | BEIGENE LTD. (KY) | 2024-11-14 | — | — | US | disclosed |
| US-12077536-B2 | BCL-2 inhibitors | BEIGENE, LTD. (KY) | 2024-09-03 | — | — | US | disclosed |
| CN-118104642-A | Emulsifier for anti-decomposition pinoxaden emulsifiable concentrate as well as preparation method and application thereof | 沧州鸿源农化有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| EP-1064287-A1 | USE OF AMINOPHOSPHONATES AS 31 P-NMR PH INDICATORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2001-01-03 | — | — | EP | disclosed |
| US-6072085-A | COMBINING SUBSTRATE IMINE, NUCLEOPHILIC ACTIVATOR, SILANE, METAL CATALYST, WHEREIN CATALYST CATALYZES REDUCTION OF IMINE BY HYDROSILATION | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-06-06 | — | — | US | disclosed |
| WO-1999047527-A1 | USE OF AMINOPHOSPHONATES AS31P NMR pH INDICATORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CN RS) (FR) | 1999-09-23 | — | — | WO | disclosed |
| US-5686616-A | Process for preparing an optically active amine | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1997-11-11 | — | — | US | disclosed |
| CN-1107475-A | Pyrrolidine derivatives inhibitors of lfukotriene biosynthesis | BOEHRINGER INGELHEIM PHARMA (US) | 1995-08-30 | — | — | CN | disclosed |
| EP-0657451-A2 | Pyrrolidine derivatives inhibitors of leukotriene biosynthesis | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1995-06-14 | — | — | EP | disclosed |
| US-5292893-A | Catalytic asymmetric and non-asymmetric reduction of times and oximes using metal catalysts | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0558656-A1 | NEW METHODS FOR THE CATALYTIC REDUCTION OF ORGANIC SUBSTRATES. | MASSACHUSETTS INST TECHNOLOGY (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992009545-A2 | NEW METHODS FOR THE CATALYTIC REDUCTION OF ORGANIC SUBSTRATES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-06-11 | — | — | WO | disclosed |
| US-3931155-A | ANTICOAGULANT | RICHARDSON-MERRELL INC. (US) | 1976-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12077536-B2 | BCL-2 inhibitors | BCL2, BCL2L1, BCL2L2 | CHRNB4 4860/4885CHRNA3 4851/4885ALDH1A1 3125/4885 |
| US-12459921-B2 | Isoindoline compound, preparation method, pharmaceutical composition and use thereof | CUL4B, CUL4A, UBQLN1 | CHRNB4 1310/4885CHRNA3 2157/4885ALDH1A1 825/4885 |
| US-20250391519-A1 | CHEMICAL SYNTHESIS PLATFORM | SET, CBS, COASY | CHRNB4 3921/4885CHRNA3 3591/4885ALDH1A1 2847/4885 |
| US-20240376104-A1 | Bcl-2 Inhibitors | BCL2, BCL2L1, BCL2L2 | CHRNB4 4860/4885CHRNA3 4851/4885ALDH1A1 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.