SCHEMBL18985455

SCHEMBL18985455

CCOC(=O)c1ccc(-c2nccc(Cl)n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.49
PDGFRA P16234 1/20 0.49
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
ESR1 P03372 1/20 0.49
CA7 P43166 1/20 0.49
CA9 Q16790 1/20 0.49
ESR2 Q92731 1/20 0.49
CA14 Q9ULX7 1/20 0.49
LMNA P02545 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 1/20 0.47
MAOA P21397 1/20 0.47
KDM4E B2RXH2 3/20 0.46
ALOX15 P16050 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
SIRT2 Q8IXJ6 1/20 0.45
SIRT1 Q96EB6 1/20 0.45
SIRT3 Q9NTG7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27771735 0.82 CA12 (0.58) PDGFRBPDGFRACA12CA1CA2
SCHEMBL4889753 0.80 MAP4K4 (0.47) PDGFRBPDGFRACA12CA1CA2
SCHEMBL2856840 0.79 CA12 (0.47) PDGFRBPDGFRACA12CA1CA2
SCHEMBL16796251 0.77 KMT2A (0.47) CA12CA1CA2CA7CA9
SCHEMBL8031197 0.77 CA12 (0.49) CA12CA1CA2ESR1CA7
SCHEMBL11562618 0.77 LMNA (0.46) PDGFRBPDGFRACA12CA1CA2
SCHEMBL4635046 0.76 CA12 (0.63) PDGFRBPDGFRACA12CA1CA2
SCHEMBL18832310 0.76 CA12 (0.47) PDGFRBPDGFRACA12CA1CA2
SCHEMBL16351874 0.76 CA1 (0.73) CA12CA1CA2ESR1CA7
SCHEMBL1965326 0.76 CA1 (0.73) CA12CA1CA2ESR1CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4253412-A2 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS The Walter and Eliza Hall Institute of Medical Research (AU) 2023-10-04 EP disclosed
EP-4253412-A2 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS The Walter and Eliza Hall Institute of Medical Research (AU) 2023-10-04 EP disclosed
US-20230192857-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2023-06-22 US disclosed
US-20230192857-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2023-06-22 US disclosed
EP-3827838-B1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2023-06-07 EP disclosed
EP-3827838-B1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2023-06-07 EP disclosed
US-11492404-B2 Inhibition of cytokine-induced SH2 protein in NK cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH 2022-11-08 US disclosed
US-20220267447-A1 Inhibition of Cytokine-Induced SH2 Protein in NK Cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2022-08-25 US disclosed
US-11339220-B2 Inhibition of cytokine-induced SH2 protein in NK cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH 2022-05-24 US disclosed
US-11339220-B2 Inhibition of cytokine-induced SH2 protein in NK cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH 2022-05-24 US disclosed
US-20210171636-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2021-06-10 US disclosed
US-20210171636-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2021-06-10 US disclosed
EP-3827838-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS The Walter and Eliza Hall Institute of Medical Research (AU) 2021-06-02 EP disclosed
EP-3827838-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS The Walter and Eliza Hall Institute of Medical Research (AU) 2021-06-02 EP disclosed
US-10975149-B2 Inhibition of cytokine-induced SH2 protein in NK cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH 2021-04-13 US disclosed
US-10975149-B2 Inhibition of cytokine-induced SH2 protein in NK cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH 2021-04-13 US disclosed
EP-3389695-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS The Walter and Eliza Hall Institute of Medical Research (AU) 2018-10-24 EP disclosed
US-20180298101-A1 Inhibition of Cytokine-Induced SH2 Protein in NK Cells THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2018-10-18 US disclosed
WO-2017100861-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2017-06-22 WO disclosed
WO-2017100861-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2017-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192857-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS IL2, ILF2, CD74 PDGFRB 1530/4885PDGFRA 2305/4885CA12 3652/4885
US-11492404-B2 Inhibition of cytokine-induced SH2 protein in NK cells IL2, ILF2, LCP2 PDGFRB 1612/4885PDGFRA 2412/4885CA12 3604/4885
US-20180298101-A1 Inhibition of Cytokine-Induced SH2 Protein in NK Cells IL2, ILF2, LCP2 PDGFRB 1612/4885PDGFRA 2412/4885CA12 3604/4885
US-11339220-B2 Inhibition of cytokine-induced SH2 protein in NK cells IL2, ILF2, LCP2 PDGFRB 1612/4885PDGFRA 2412/4885CA12 3604/4885
US-20210171636-A1 INHIBITION OF CYTOKINE-INDUCED SH2 PROTEIN IN NK CELLS IL2, ILF2, CD74 PDGFRB 1530/4885PDGFRA 2305/4885CA12 3652/4885
US-20220267447-A1 Inhibition of Cytokine-Induced SH2 Protein in NK Cells IL2, ILF2, CD74 PDGFRB 1530/4885PDGFRA 2305/4885CA12 3652/4885
US-10975149-B2 Inhibition of cytokine-induced SH2 protein in NK cells IL2, ILF2, LCP2 PDGFRB 1612/4885PDGFRA 2412/4885CA12 3604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.