Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | PRNP | P04156 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1898571 | 0.90 | ANO1 (0.61) | MEN1KMT2APRNPATML3MBTL1 | |
| SCHEMBL1953737 | 0.84 | ANO1 (0.58) | MEN1KMT2APRNPATML3MBTL1 | |
| SCHEMBL1951568 | 0.80 | MEN1 (0.71) | MEN1KMT2APRNPATML3MBTL1 | |
| SCHEMBL12314161 | 0.77 | MEN1 (0.70) | MEN1KMT2APRNPATML3MBTL1 | |
| SCHEMBL1894024 | 0.77 | ANO1 (0.54) | MEN1KMT2AMAPTTP53THRB | |
| SCHEMBL1952997 | 0.74 | ANO1 (0.71) | ANO1 | |
| SCHEMBL1906603 | 0.73 | MEN1 (0.55) | MEN1KMT2APRNPATML3MBTL1 | |
| SCHEMBL13837638 | 0.71 | TP53 (0.60) | MEN1KMT2AMAPTTP53THRB | |
| SCHEMBL3629317 | 0.71 | ANO1 (0.71) | ANO1 | |
| SCHEMBL13837779 | 0.70 | MAPT (0.56) | MEN1KMT2AMAPTTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |