Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894021 | 0.91 | ANO1 (0.66) | ANO1MAPTTHRBTDP1MEN1 | |
| SCHEMBL1951555 | 0.83 | ANO1 (0.77) | ANO1MAPTHTTMEN1KMT2A | |
| SCHEMBL1953916 | 0.81 | ANO1 (0.56) | ANO1MAPTTHRBTDP1MEN1 | |
| SCHEMBL1898573 | 0.77 | MEN1 (0.51) | ANO1MAPTTHRBHTTTP53 | |
| SCHEMBL14156254 | 0.71 | HTT (0.53) | ANO1MAPTHTTKMT2AKDM4E | |
| SCHEMBL13819666 | 0.71 | MEN1 (0.65) | ANO1MEN1KMT2APKMNPC1 | |
| SCHEMBL1953247 | 0.71 | ANO1 (1.00) | ANO1 | |
| SCHEMBL21247530 | 0.70 | MEN1 (0.65) | ANO1HTTTP53MEN1KMT2A | |
| SCHEMBL4124608 | 0.70 | CASP3 (0.72) | ANO1MAPTTHRBTDP1MEN1 | |
| SCHEMBL1906603 | 0.70 | MEN1 (0.55) | ANO1MAPTMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |