Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186662 | 0.89 | LMNA (0.31) | TACR3LMNAGAA | |
| SCHEMBL26091805 | 0.80 | TACR3 (0.37) | TACR3DPP8DPP7LMNAGAA | |
| SCHEMBL26091064 | 0.80 | TACR3 (0.37) | TACR3DPP8DPP7LMNAGAA | |
| SCHEMBL26091072 | 0.80 | TACR3 (0.37) | TACR3DPP8DPP7LMNAGAA | |
| SCHEMBL1903186 | 0.77 | EPHX1 (0.44) | — | |
| SCHEMBL28568677 | 0.77 | TACR3 (0.36) | TACR3DPP8DPP7LMNAGAA | |
| SCHEMBL4328443 | 0.77 | TACR3 (0.37) | TACR3DPP8DPP7LMNA | |
| SCHEMBL20702384 | 0.77 | TACR3 (0.37) | TACR3DPP8DPP7LMNA | |
| SCHEMBL20702387 | 0.77 | TACR3 (0.37) | TACR3DPP8DPP7LMNA | |
| SCHEMBL25335914 | 0.76 | TACR3 (0.39) | TACR3DPP8DPP7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320907-A1 | THERAPEUTIC COMPOUNDS | Merck & Co., Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010017047-A1 | THERAPEUTIC COMPOUNDS | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |