Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 20/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19001457 | 0.76 | APLNR (0.41) | APLNR | |
| SCHEMBL28644394 | 0.75 | APLNR (0.39) | APLNR | |
| SCHEMBL19001438 | 0.72 | APLNR (0.39) | APLNR | |
| SCHEMBL19001460 | 0.72 | APLNR (0.40) | APLNR | |
| SCHEMBL20584407 | 0.71 | APLNR (0.53) | APLNR | |
| SCHEMBL20584792 | 0.70 | APLNR (0.42) | APLNR | |
| SCHEMBL19001458 | 0.70 | APLNR (0.49) | APLNR | |
| SCHEMBL19376223 | 0.70 | APLNR (0.65) | APLNR | |
| SCHEMBL19376224 | 0.70 | APLNR (0.65) | APLNR | |
| SCHEMBL19376076 | 0.70 | APLNR (0.65) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390400-A1 | HETEROARYLHYDROXYPYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR | Bristol-Myers Squibb Company (US) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017106396-A1 | HETEROARYLHYDROXYPYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-06-22 | — | — | WO | disclosed |