Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689228 | 0.90 | DHODH (0.82) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL2467110 | 0.86 | DHODH (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL29536364 | 0.86 | DHODH (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL7588217 | 0.86 | KDM4E (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL29376617 | 0.86 | KDM4E (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL25519 | 0.86 | KDM4E (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL22471905 | 0.86 | HSD17B10 (0.70) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL4009455 | 0.86 | DHODH (0.76) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL4017739 | 0.85 | DHODH (0.80) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL29788466 | 0.85 | DHODH (0.80) | DHODHKDM4EPDE10ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2325181-B1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | GENERAL INCORPORATED ASS PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) | 2017-03-29 | — | — | EP | disclosed |
| CN-102099352-B | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INC ASS | 2014-02-26 | — | — | CN | disclosed |
| US-8466290-B2 | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INCORPORATED ASSOCIATION (JP) | 2013-06-18 | — | — | US | disclosed |
| US-20110172429-A1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | PHARMA IP GENERAL INCORPORATED ASSOCIATION (JP) | 2011-07-14 | — | — | US | disclosed |
| CN-102099352-A | STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient | PHARMA IP GENERAL INC ASS | 2011-06-15 | — | — | CN | disclosed |
| EP-2325181-A1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | Pharma Ip General Incorporated Association (JP) | 2011-05-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172429-A1 | STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT | STAT3, STAT4, STAT5B | DHODH 3326/4885KDM4E 532/4885PDE10A 3560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.