Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.93 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.93 |
| ▸ | LMNA | P02545 | 1/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.93 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.73 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.73 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467110 | 1.00 | DHODH (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL29376617 | 0.97 | KDM4E (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL25519 | 0.97 | KDM4E (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL7588217 | 0.97 | KDM4E (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL4805149 | 0.95 | KDM4E (0.97) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL10757475 | 0.95 | KDM4E (0.97) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL4464779 | 0.95 | KDM4E (0.97) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| Cinchophen SCHEMBL27543969 | 0.93 | KDM4E (0.93) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL3237037 | 0.90 | POLB (1.00) | DHODHKDM4EPDE10ALMNASMN1; SMN2 | |
| SCHEMBL8689228 | 0.90 | DHODH (0.82) | DHODHKDM4EPDE10ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117050110-A | GPX4 and DHODH double-inhibition small molecule prodrug compound based on mitochondrial targeting and preparation method and application thereof | 厦门大学 | 2023-11-14 | — | — | CN | claimed |
| CN-117327011-A | Quinoline PCSK9 inhibitor and preparation method and application thereof | 山东省分析测试中心 | 2024-01-02 | — | — | CN | disclosed |
| CN-117050110-A | GPX4 and DHODH double-inhibition small molecule prodrug compound based on mitochondrial targeting and preparation method and application thereof | 厦门大学 | 2023-11-14 | — | — | CN | disclosed |
| EP-3976594-A1 | A THERAPEUTIC APPROACH FOR TREATING NON-INFECTIOUS OCULAR IMMUNOINFLAMMATORY DISORDERS | The Schepens Eye Research Institute, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |