SCHEMBL18993199

SCHEMBL18993199

CC(C)(C)OC(=O)N1CC2(CC2)C[C@H]1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc(C6C7CC[C@H](C7)N6C(=O)OC(C)(C)C)[nH]c5c4)ccc2-3)[nH]1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PRCP P42785 2/20 0.34
HPGDS O60760 3/20 0.31
TBK1 Q9UHD2 1/20 0.31
CHEK2 O96017 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19093147 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL19981517 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL19186343 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL19981456 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL19186314 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL16541580 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL19607443 1.00 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL19186622 0.94 PRCP (0.32) PRCPHPGDSTBK1CHEK2
SCHEMBL15368147 0.92 PRCP (0.34) PRCPHPGDSTBK1CHEK2
SCHEMBL204130 0.92 PRCP (0.34) PRCPHPGDSTBK1CHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9682987-B2 Solid forms of an antiviral compound GILEAD PHARMASSET LLC (US) 2017-06-20 US disclosed