Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094951 | 0.90 | JAK2 (0.53) | JAK2NTRK1USP2TSHRSCN3A | |
| SCHEMBL4296488 | 0.82 | JAK2 (0.51) | JAK2NTRK1USP2TSHRMAPK1 | |
| SCHEMBL16426169 | 0.79 | JAK2 (0.49) | JAK2NTRK1USP2TSHRMAPK1 | |
| SCHEMBL4106164 | 0.71 | JAK2 (0.50) | JAK2NTRK1SCN3AHRH3 | |
| SCHEMBL4106152 | 0.69 | NTRK1 (0.52) | JAK2NTRK1USP2TSHRMEN1 | |
| SCHEMBL19547145 | 0.65 | JAK2 (0.33) | JAK2NTRK1SCN3A | |
| SCHEMBL18812935 | 0.64 | JAK2 (0.56) | JAK2NTRK1 | |
| SCHEMBL19547155 | 0.63 | JAK2 (0.33) | JAK2NTRK1 | |
| SCHEMBL19560120 | 0.63 | NTRK1 (0.55) | JAK2NTRK1MEN1KMT2A | |
| SCHEMBL4102082 | 0.63 | RIPK1 (0.37) | NTRK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682979-B2 | Substituted pyrazolo [1,5-A] pyrimidine compounds as TRK kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-06-20 | — | — | US | disclosed |