Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18994284 | 0.73 | GUSB (0.41) | GUSBMAOAMAOB | |
| SCHEMBL18994272 | 0.68 | DUSP1 (0.52) | GUSBALDH1A1HPGD | |
| SCHEMBL18994264 | 0.67 | DUSP1 (0.54) | GUSBALDH1A1 | |
| SCHEMBL3701762 | 0.67 | DUSP1 (0.54) | GUSBALDH1A1 | |
| SCHEMBL3701763 | 0.67 | DUSP1 (0.54) | GUSBALDH1A1 | |
| SCHEMBL3628239 | 0.64 | MAOA (0.60) | ALDH1A1MAOAMAOBKDM4EHPGD | |
| SCHEMBL31124667 | 0.64 | MEN1 (0.35) | ALDH1A1MAOAMAOBKDM4EHPGD | |
| SCHEMBL29638852 | 0.64 | MAOA (0.60) | ALDH1A1MAOAMAOBKDM4EHPGD | |
| SCHEMBL29503343 | 0.64 | MAOA (0.60) | ALDH1A1MAOAMAOBKDM4EHPGD | |
| SCHEMBL18994291 | 0.62 | CAMK2A (0.46) | GUSBMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682919-B2 | Small molecule inhibitors of Dusp6 and uses therefor | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-06-20 | — | — | US | disclosed |