Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1738564 | 0.77 | FABP6 (0.34) | — | |
| SCHEMBL1737055 | 0.67 | AXL (0.34) | — | |
| SCHEMBL3877175 | 0.67 | HPGD (0.40) | KDM4EMAPTHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL29155626 | 0.65 | HPGD (0.40) | KDM4EMAPTHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL7251774 | 0.62 | L3MBTL1 (0.42) | KDM4EMAPTHPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL3257090 | 0.62 | KMT2A (0.46) | KDM4EMAPTHPGDSMN1; SMN2NPC1 | |
| SCHEMBL17500019 | 0.62 | FABP6 (0.36) | KDM4EMAPTALDH1A1 | |
| SCHEMBL3577936 | 0.61 | KDM6B (0.58) | KDM4EHPGDL3MBTL1NPC1POLB | |
| SCHEMBL22496911 | 0.61 | JAK2 (0.34) | — | |
| SCHEMBL5764763 | 0.60 | HPGD (0.37) | KDM4EMAPTHPGDSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124715-A1 | Antiviral Oligonucleotides Having a Conserved G4 Core Sequence | HANECAK RONNIE C | 2011-05-26 | — | — | US | disclosed |
| US-20070015723-A1 | Antiviral oligonucleotides having a conserved G4 core sequence | ISIS PHARMACEUTICALS, INC. | 2007-01-18 | — | — | US | disclosed |
| EP-0672193-B1 | USE OF OLIGONUCLEOTIDES HAVING A CONSERVED G 4 CORE SEQUENCE FOR THE PREPARATION OF A MEDICAMENT | ISIS PHARMACEUTICALS INC (US) | 2002-08-14 | — | — | EP | disclosed |
| EP-1016715-A1 | Oligonucleotides having a conserved G4 core sequence | ISIS PHARMACEUTICALS, INC. (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-0691980-B1 | 7-DEAZAPURINE MODIFIED OLIGONUCLEOTIDES | SANOFI SA (FR) | 1997-06-04 | — | — | EP | disclosed |
| EP-0691980-A1 | 7-DEAZAPURINE MODIFIED OLIGONUCLEOTIDES | STERLING WINTHROP INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0672193-A1 | OLIGONUCLEOTIDES HAVING A CONSERVED G 4? CORE SEQUENCE | ISIS PHARMACEUTICALS, INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994022892-A1 | 7-DEAZAPURINE MODIFIED OLIGONUCLEOTIDES | STERLING WINTHROP INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| WO-1994008053-A1 | OLIGONUCLEOTIDES HAVING A CONSERVED G4 CORE SEQUENCE | ISIS PHARMACEUTICALS, INC. (US) | 1994-04-14 | — | — | WO | disclosed |