Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.60 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.60 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12451637 | 0.88 | HSD17B3 (0.68) | HSD17B3KDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL8594115 | 0.83 | HSD17B3 (0.68) | HSD17B3KDM4EALDH1A1TSHRALDH1A2 | |
| SCHEMBL12302921 | 0.83 | HSD17B3 (0.68) | HSD17B3KDM4EALDH1A1TSHRALDH1A2 | |
| SCHEMBL536846 | 0.83 | HSD17B3 (1.00) | HSD17B3KDM4EALDH1A1TDP1GAA | |
| SCHEMBL4417415 | 0.82 | NPC1 (0.58) | HSD17B3ALDH1A1TDP1GAAHPGD | |
| SCHEMBL5969658 | 0.82 | KMT2A (0.59) | KDM4EALDH1A1TDP1GAAHSD17B10 | |
| SCHEMBL10330392 | 0.82 | RAB9A (0.61) | HSD17B3ALDH1A1TDP1GAAHSD17B10 | |
| SCHEMBL12879918 | 0.81 | RAB9A (0.55) | HSD17B3KDM4EALDH1A1MAPTTDP1 | |
| SCHEMBL12251339 | 0.80 | HSD17B3 (0.65) | HSD17B3KDM4EALDH1A1TSHRALDH1A2 | |
| SCHEMBL15984893 | 0.80 | KDM4E (0.71) | HSD17B3KDM4EALDH1A1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174699-A1 | COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE | SHY Therapeutics LLC | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174699-A1 | COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE | MAPK6, MAP3K6, MAPK4 | HSD17B3 2191/4885KDM4E 3392/4885ALDH1A1 2765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.