Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | GABRP | O00591 | 1/20 | 0.79 |
| ▸ | GABRD | O14764 | 1/20 | 0.79 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.79 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.79 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.79 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.79 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.79 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.79 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.79 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.79 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.79 |
| ▸ | GABRE | P78334 | 1/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.79 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.79 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.79 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.79 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isonipecotic Acid SCHEMBL23043998 | 0.92 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL104297 | 0.88 | — | — | |
| Isonipecotic Acid SCHEMBL2027408 | 0.88 | TSHR (1.00) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6665012 | 0.87 | TSHR (0.67) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL5035880 | 0.86 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL2560208 | 0.86 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL6122239 | 0.86 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL1703706 | 0.86 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL31602943 | 0.86 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL30060745 | 0.86 | TSHR (0.94) | TSHRGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104710408-A | Chiral cis-imidazolines | HOFFMANN LA ROCHE | 2015-06-17 | — | — | CN | disclosed |
| US-8513239-B2 | Chiral cis-imidazolines | HOFFMANN-LA ROCHE INC. (US) | 2013-08-20 | — | — | US | disclosed |
| EP-2203437-B1 | CHIRAL CIS-IMIDAZOLINES | HOFFMANN LA ROCHE (CH) | 2012-11-07 | — | — | EP | disclosed |
| EP-2325180-A1 | Chiral CIS-imidazolines | F. Hoffmann-La Roche AG (CH) | 2011-05-25 | — | — | EP | disclosed |
| CN-101821251-A | Chiral cis-imidazolines | HOFFMANN LA ROCHE | 2010-09-01 | — | — | CN | disclosed |
| US-20090111789-A1 | CHIRAL CIS-IMIDAZOLINES | HOFFMANN-LA ROCHE, INC. | 2009-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111789-A1 | CHIRAL CIS-IMIDAZOLINES | FOXM1, CCNE1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TSHR 1143/4885GABRP 2721/4885GABRD 4444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.