Isonipecotic Acid

Isonipecotic Acid

SCHEMBL1703706

Cl.O=C(O)C1CCNCC1

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Isonipecotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRP known ✓ O00591 1/20 0.94
GABRD known ✓ O14764 1/20 0.94
GABRA1 known ✓ P14867 1/20 0.94
GABRB1 known ✓ P18505 1/20 0.94
GABRG2 known ✓ P18507 1/20 0.94
GABRB3 known ✓ P28472 1/20 0.94
GABRA5 known ✓ P31644 1/20 0.94
GABRA3 known ✓ P34903 1/20 0.94
GABRA2 known ✓ P47869 1/20 0.94
GABRB2 known ✓ P47870 1/20 0.94
GABRA4 known ✓ P48169 1/20 0.94
GABRE known ✓ P78334 1/20 0.94
GABRA6 known ✓ Q16445 1/20 0.94
GABRG1 known ✓ Q8N1C3 1/20 0.94
GABRG3 known ✓ Q99928 1/20 0.94
GABRQ known ✓ Q9UN88 1/20 0.94
SLC6A1 known ✓ P30531 2/20 0.50
CHRNA3 known ✓ P32297 1/20 0.39
TSHR P16473 2/20 0.94
PMP22 Q01453 1/20 0.94

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isonipecotic Acid SCHEMBL2560208 1.00 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL31602943 1.00 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL104297 0.97
Isonipecotic Acid SCHEMBL2027408 0.97 TSHR (1.00) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL23043998 0.94 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL5035880 0.94 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL6122239 0.94 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL30060745 0.94 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL11556866 0.94 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1
Isonipecotic Acid SCHEMBL28089924 0.94 TSHR (0.94) TSHRGABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116601149-A Aminoquinazoline derivatives as P2X3 inhibitors 奇斯药制品公司 2023-08-15 CN claimed
CN-115322143-B Preparation method of 4-tert-butyl piperidine formate hydrochloride 安徽德诺医药股份有限公司 2023-07-14 CN claimed
CN-115322143-A Preparation method of 4-piperidine formic acid tert-butyl ester hydrochloride 安徽德诺医药股份有限公司 2022-11-11 CN claimed
CN-108707151-A Pyrimido-pyridazinone compound and application thereof 阿萨纳生物科技有限责任公司 2018-10-26 CN claimed
CN-108601785-A Purposes of the pyrimido pyridazinone in treating cancer 阿沙纳生物科学公司 2018-09-28 CN claimed
CN-103974955-B Pyrimido-pyridazinone compounds and uses thereof 阿萨纳生物科技有限责任公司 2018-06-19 CN claimed
CN-103974955-A Pyrimido-pyridazinone compounds and uses thereof ENDO PHARMACEUTICALS INC 2014-08-06 CN claimed
US-12383548-B2 Antibacterial quinolines Tecnimede—Sociedade Técnico-Medicinal, SA (PT) 2025-08-12 US disclosed
US-20240336601-A1 4-PHENYL-INDOLE DERIVATIVES AND RELATED USES CHULALONG UNIVERSITY (TH) 2024-10-10 US disclosed
US-20240228461-A1 NOVEL METHOD FOR PREPARING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST LG CHEM, LTD. (KR) 2024-07-11 US disclosed
CN-117222632-A Crystalline forms of sphingosine-1-phosphate receptor agonists 株式会社LG化学 2023-12-12 CN disclosed
CN-114728917-B Oxamide derivative, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2023-12-08 CN disclosed
CN-117202893-A Directly compressible pharmaceutical compositions comprising sphingosine-1-phosphate receptor agonists 株式会社LG化学 2023-12-08 CN disclosed
WO-2006073361-A1 NOVEL PYRIDINE COMPOUNDS ASTRAZENECA AB (SE) 2006-07-13 WO disclosed
CN-1742013-A Pyrazolopyrimidine compound and method for producing the same TANABE SEIYAKU CO (JP) 2006-03-01 CN disclosed
WO-2006020719-A2 AMINOACID CONJUGATES OF BETA - LAPACHONE FOR TUMOR TARGETING ARQULE, INC. (US) 2006-02-23 WO disclosed
CN-1723210-A Fused furan compound TANABE SEIYAKU CO (JP) 2006-01-18 CN disclosed
CN-1483031-A Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them ���ĵ�˹ҩ��ɷ����޹�˾ 2004-03-17 CN disclosed
CN-1279669-A Aromatic sulfone hydroxamic acid metalloprotease inhibitors SEARLE & CO (US) 2001-01-10 CN disclosed
EP-0208235-B1 N-ARALKYL PIPERIDINEMETHANOL DERIVATIVES MERRELL DOW PHARMACEUTICALS INC. (US) 1990-01-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12383548-B2 Antibacterial quinolines NQO2, RABGGTB, NQO1 GABRP 2825/4885GABRD 2160/4885GABRA1 3643/4885
US-20240336601-A1 4-PHENYL-INDOLE DERIVATIVES AND RELATED USES PDCD1, PDCD1LG2, CD274 GABRP 560/4885GABRD 2760/4885GABRA1 2384/4885
US-20240228461-A1 NOVEL METHOD FOR PREPARING SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST S1PR1, S1PR2, S1PR5 GABRP 323/4885GABRD 1094/4885GABRA1 392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.