Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2759552 | 0.85 | HRH4 (0.49) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL11988947 | 0.83 | SMO (0.52) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL5122324 | 0.83 | HTR3A (0.47) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL12675278 | 0.83 | HTR3A (0.47) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL8281445 | 0.82 | HRH4 (0.46) | HTR3AHTR1ADRD2DRD4HTR2A | |
| Hydrochloric Acid SCHEMBL5009806 | 0.82 | HTR3A (0.46) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL15237594 | 0.81 | RET (0.38) | HTR1ADRD2DRD4HTR2AHTR2C | |
| SCHEMBL6222902 | 0.81 | AOC3 (0.46) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL18924316 | 0.81 | HTR3A (0.45) | HTR3AHTR1ADRD2DRD4HTR2A | |
| SCHEMBL22792254 | 0.81 | SMO (0.56) | HTR3AHTR1ADRD2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |